Program

Thursday, November 7th, 2013

7:15AM – Breakfast

8:00AM –  Luis Diaz, Johns Hopkins Kimmel Cancer Center – Welcome

Session 1 – Circulating nucleic acids in Cancer

Chair: Frank Diehl, PhD, VP Lab Operations and R&D, Sysmex Inostics GmbH

8:10AM – Plenary Session

Bert Vogelstein, Clayton Professor of Oncology and HHMI Investigator at Johns Hopkins, Baltimore, Maryland, USA
 

8:50AM – Oral Abstract Presentation #1 – Chris Karlovich, Principal Scientist, Clovis Oncology – “Serial monitoring of EGFR mutations in plasma and evaluation of EGFR mutation status in matched tissue and plasma from NSCLC patients treated with CO-1686”

9:05AM – Oral Abstract Presentation #2 – Alain Thierry, Institut de Recherche en Cancérologie de Montpellier – “Reliable analysis of circulating cell-free DNA: Validation of the clinical diagnostic application of the determination of KRAS/BRAF mutational status in colorectal cancer patients”

9:20AM – Frank Diehl, PhD, VP Lab Operations and R&D, Sysmex Inostics GmbH  – “Routine clinical testing experience based on circulating tumor DNA”

9:45AM – Break

9:55AM – James Herman, Professor of Oncology, Johns Hopkins Kimmel Cancer Center – “Analysis of methylation in circulating tumor DNA”

10:20AM – Nitzan Rosenfeld, Cancer Research UK Cambridge Institute and University of Cambridge – “Tracking the Cancer Genome in Plasma by ctDNA”

10:45AM – Michael Jeffers, Experimental Medicine Scientist, Bayer AG – “Detection of primary and secondary KIT mutations in plasma DNA obtained from GIST patients enrolled in the GRID phase III trial

11:10AM - Dennis Lo, Professor of Medicine and Chemical Pathology, The Chinese University of Hong Kong – “Plasma DNA sequencing for cancer detection”

11:35AM - Victor Velculescu, Professor of Oncology, Johns Hopkins Kimmel Cancer Center – “Whole Genome Analyses of Circulating Tumor DNA”

MEET THE EXPERTS & LUNCH

Meeting Faculty will be available for face-to-face discussions

 

Session 2 – Technology to assess circulating nucleic acids

Chair: Kenneth W. Kinzler, Professor of Oncology at Johns Hopkins, Baltimore, Maryland, USA

1:00PM – Plenary Session

Steven Quake, Professor of Bioengineering and HHMI Investigator, Stanford University, Palo Alto, California, USA
 

1:45PM  -  Oral Abstract Presentation #1 – Thessalia Papasavva, Scientific Research Officer, The Cyprus Institute of Neurology and Genetics – “Evaluation of High Resolution Melting analysis for the detection of paternally inherited alleles in the maternal plasma for the non-invasive prenatal diagnosis of β-thalassaemia.”

2:00PM  -  Oral Abstract Presentation #2 – Paul Scheet, Associate Professor, MD Anderson Cancer Center – “New Computational Techniques for Detecting Allelic Imbalance”

2:15PM  -  Andre Marziali, Chief Scientific Officer, Boreal Genomics – “Mutation detection and monitoring of cell-free tumor DNA in plasma using targeted-allele analysis”

2:40PM  -  Tal Raz, VP Molecular Biology, GnuBIO Inc. -  “Fully integrated DNA sequencing. Sample to answer target enrichment, sequencing and analysis”

3:05PM  -  Break

3:15PM  –  Darren Link, Co-Founder and Vice President, Research and Development, Raindance Technologies – “Digital PCR with Pico-Liter Droplets”

3:40PM  –  George Karlin-Neumann, Director of Scientific Affairs – Digital Biology Center, Bio-Rad Laboratories Inc, “Mining the Bloodstream for Signs of Disease with Droplet Digital PCR”

4:05PM  –  Charles Cantor, Ph.D., Chief Scientific Officer, Sequenom, Inc. – “Sensitive detection of minor alleles in plasma and other heterogeneous samples”

4:30PM  –  Richard Rava, Vice-President, Research & Development, Verinata Health  - “Non-Invasive Detection of Sub-Chromosomal Variants Across the Genome using Molecular Counting of Cell-Free DNA”

5:00PM – Discussion

5:15PM –  Final Remarks

Poster Session (5:00 – 7:00 PM)

Chair: Matthias Holdhoff, Assistant Professor of Oncology, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland

Cocktails & Hors d’oeuvres

6:00PM  - Introduction & Oral Presentations

 

Friday, November 8th, 2013

7:15AM – Breakfast

8:00AM –  Luis Diaz, Johns Hopkins Kimmel Cancer Center – Welcome

 

Session 3 – Circulating nucleic acids in Maternal Fetal Medicine

Chair: Lyn Chitty,  Professor of Genetics and Fetal Medicine, UCL Institute of Child Health, Great Ormond Street and UCLH NHS Foundations Trusts, London

8:10AM – Plenary Session

Dennis Lo, Professor of Medicine and Chemical Pathology and Associate Dean of Research for The Chinese University of Hong Kong

8:50AM – Oral Abstract Presentation #1 – Sara Perlado, Fundacion Jimenez Diaz, Spain – “NIPD of Monogenic Disorders in the clinical practice: experience in 301 cases”

9:05AM – Oral Abstract Presentation #2 – Joshua Babiarz, Senior Scientist, Natera Inc, “Non-invasive Prenatal Detection of Microdeletions using SNP-targeted sequencing”

9:20AM – Oral Abstract Presentation #3 – Winston Koh, Stanford University – “Non-invasive in vivo monitoring of global gene expression from the human fetus”

9:45AM - Brigitte Faas, Ph.D., University Medical Centre Nijmegen, Netherlands, “Noninvasive Prenatal Testing for Fetal Aneuploidies Using ccffDNA in Maternal Plasma: An Overview

10:10AM - Lyn Chitty, UCL Institute of Child Health, Great Ormond Street and UCLH NHS Foundations Trusts – “Noninvasive prenatal diagnosis for monogenic disorders”

10:35AM - Subhashini Chandrasekharan, Assistant Research Professor, Institute for Genome Sciences & Policy at Duke – “Global Commercialization of Non-invasive Prenatal Testing – Implications for Clinical Adoption and Patient Access”

11:00AM - Break

 

Session 4 – Special Session  - Legal, Regulatory and Clinical Considerations of CNAPS

Chair: Chetan Bettegowda, Assistant Professor of Oncology, Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.

11:10AM - Daniel F. Hayes, Stuart B. Padnos Professor of Breast Cancer Research, The University of Michigan – “Vicious Cycle”

11:35AM – Eunice Lee,  Office of In Vitro Diagnostics and Radiological Health, Food and Drug Administration - “Regulatory considerations in the development of diagnostics for circulating nucleic acids”

12:00PM - Thomas Meyers, Brown Rudnick LLP – “Legal considerations for new genomic technologies and their commercial and clinical application”

 

MEET THE EXPERTS & LUNCH

Meeting Faculty will be available for face-to-face discussions

 

Session 5– Novel approaches for the analysis of circulating nucleic acids

Chair: Muneesh Tewari, Associate Member, Fred Hutchison Cancer Research Center, Seattle, WA

1:30PM -  Oral Abstract Presentation #1 – Iwijn De Vlaminck, Stanford University – “Sequencing of plasma DNA for diagnosis of rejection and infection in organ transplantation”

1:45PM -  Oral Abstract Presentation #2 – Sándor Spisák, Children’s Hospital, Harvard Medical School, Boston, MA, USA – “Large DNA fragments can pass from GI tract to blood – metagenome analysis of human plasma samples”

2:00PM - Anna Zampetaki, Lecturer, King’s College London – “Circulating miRNAs: Rewired networks and Cardiovascular Risk”

2:25PM  -  Muneesh Tewari, Associate Member, Fred Hutchison Cancer Research Center – “Circulating microRNAs as Cancer Biomarkers”

2:50PM – Saraswati Sukumar, Professor of Oncology and Pathology, Johns Hopkins Kimmel Cancer Center - “cMethDNA, a noninvasive circulating methylated DNA assay for detection of metastatic breast cancer in blood and for monitoring response to therapy”

3:15PM  -  Johan Skog, Chief Scientific Officer, Exosome Diagnostics, Inc – “Exosome RNA profiling in biofluids as a platform for molecular diagnostics”

3:40PM  - Final Remarks